Which of the following factors can negatively impact the ACE/ACE II ratio?

• A. Regular exercise
• B. Chronic stress
• C. Diabetes
• D. Healthy diet

Answer: (C)

The ACE/ACE II ratio is an important aspect of the renin-angiotensin system, which plays a significant role in blood pressure regulation and cardiovascular health. The balance between angiotensin-converting enzyme (ACE) and its homologue ACE II is critical for maintaining vascular homeostasis.

In the case of diabetes, there is often an increase in the activity of ACE relative to ACE II. This imbalance may be attributed to several factors, including the inflammatory processes that accompany diabetes, elevated glucose levels, and the overall dysregulation of the renin-angiotensin system seen in diabetic patients. The increase in ACE, along with the potential decrease in ACE II, leads to a higher ACE/ACE II ratio, which can exacerbate complications such as hypertension and cardiovascular diseases commonly associated with diabetes.

In contrast, regular exercise, chronic stress, and a healthy diet generally contribute to cardiovascular health and can potentially promote a more favorable ACE/ACE II balance. Regular physical activity has been shown to have beneficial effects on the components of the renin-angiotensin system. Chronic stress, while it can have various negative impacts on health, does not have as direct an effect on the ACE/ACE II ratio as diabetes does. A healthy diet