Which of the following conditions would cause a "right shift" of the oxygen-hemoglobin dissociation curve?

• A. Alkalosis
• B. Hypocapnia
• C. Increased temperature
• D. Decreased 2,3 DPG

Answer: (C)

A right shift of the oxygen-hemoglobin dissociation curve indicates a decrease in hemoglobin's affinity for oxygen. This means that oxygen is more readily released from hemoglobin into the tissues, which is a response to certain physiological conditions. Increased temperature is one of the key factors that can lead to this right shift.

When body temperature rises, for example during exercise or fever, it enhances the release of oxygen from hemoglobin. This occurs because elevated temperatures increase metabolic activity in tissues, which require more oxygen. The body compensates for this heightened demand by facilitating the release of oxygen from hemoglobin, represented by the right shift on the dissociation curve.

In contrast, conditions such as alkalosis or hypocapnia can lead to a left shift of the dissociation curve, indicating increased affinity of hemoglobin for oxygen, making it more difficult for oxygen to be released to the tissues. Additionally, decreased levels of 2,3 DPG (2,3-diphosphoglycerate) in red blood cells also promote a left shift, as 2,3 DPG normally binds with hemoglobin and facilitates oxygen release. Hence, the increase in temperature is the condition most directly associated with a right shift in the oxygen-hemoglobin diss