What is the characteristic timeframe for the onset of symptoms in the late phase of an acute asthma attack?

• A. 30 minutes after the initial response
• B. 1-2 hours after the initial response
• C. 3-4 hours after the initial response
• D. 12-24 hours after the initial response

Answer: (C)

The onset of symptoms in the late phase of an acute asthma attack typically occurs 3 to 4 hours after the initial response. The acute phase of an asthma attack is characterized by immediate bronchoconstriction and other airway responses that trigger symptoms such as wheezing and shortness of breath shortly after exposure to the trigger, which can happen within minutes.

Following this immediate response, the late phase is marked by a more complex inflammatory process, involving the recruitment of immune cells, such as eosinophils and neutrophils, and the release of inflammatory mediators. This phase can lead to prolonged airway inflammation and hypersensitivity, usually manifesting within several hours after the initial bronchoconstriction.

Recognizing the timeframe of the late phase is crucial for understanding patient management, as it often requires additional interventions to alleviate the secondary inflammation and prevent prolonged symptoms. This information can guide decisions on medications, such as corticosteroids, which are more effective during this phase of inflammation, influencing overall asthma management strategies.