What characterizes Asthma-COPD overlap syndrome?

• A. Acute airway obstruction with minimal symptoms
• B. Persistent airflow limitation with features of both asthma and COPD
• C. Complete reversibility of bronchoconstriction
• D. Only chronic cough without wheezing

Answer: (B)

Asthma-COPD overlap syndrome is characterized by persistent airflow limitation that incorporates features of both asthma and chronic obstructive pulmonary disease (COPD). This syndrome is identified by a combination of symptoms, which may include wheezing, shortness of breath, and chronic cough, as well as the observable effects of both diseases on lung function.

In individuals with this overlap syndrome, there are often varying degrees of airway responsiveness that are typical of asthma, alongside the irreversible airflow limitation seen in COPD. The coexistence of these two conditions can complicate management, as treatment strategies must address the unique aspects of both asthma and COPD simultaneously. This complexity emphasizes the characteristic nature of persistent airflow limitation rather than complete reversibility, acute episodes, or isolated symptoms such as chronic cough without wheezing.