ACE II counteracts the negative consequences of which enzyme?

• A. Renin
• B. ACE II itself
• C. ACE
• D. Angiotensin I

Answer: (C)

The correct choice highlights the role of ACE II (Angiotensin-Converting Enzyme II) in counteracting the negative effects brought about by ACE (Angiotensin-Converting Enzyme). ACE is responsible for converting Angiotensin I to Angiotensin II, a potent vasoconstrictor that can lead to increased blood pressure and other detrimental cardiovascular effects.

ACE II plays a critical role in the renin-angiotensin system by converting Angiotensin II back into Angiotensin-(1-7), which has vasodilatory properties and is generally considered protective against the adverse effects of Angiotensin II. This action of ACE II helps to mitigate the negative consequences associated with heightened levels of Angiotensin II, such as hypertension, inflammation, and cardiovascular remodeling.

Understanding the balance between ACE and ACE II is crucial in the context of cardiovascular health. While ACE promotes vasoconstriction and fluid retention, ACE II works to promote vasodilation, natriuresis, and anti-inflammatory effects, thereby helping to maintain homeostasis within the cardiovascular system.